Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 64 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%

Top Medical Research Studies

9
Vitamin D3 correction improves pain
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
9
Effectiveness of calcitriol combination therapy
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.

Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.

Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
8
Vitamin D reduces fracture risk
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.

Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.

In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Read More

Most Useful Reviews

8.8
Bone pain relief
After using the supplement for 4 months, my vitamin D levels improved significantly. I experienced a 50% decrease in hair loss, and bone pain is no longer an issue. My memory has also improved greatly, with no sign of forgetfulness. The capsules are easy to swallow.
Read More
9.5
Pain alleviation
This product works like magic. One pill effectively alleviates my back and leg pain. It’s high-quality with excellent ingredients, providing good value for the price. I highly recommend sticking to the dosage of one pill weekly.
Read More
9.5
Supports immunity
Vitamin D3 is essential, particularly for those with immune issues and joint pain. It also fights fatigue and enhances immunity. Taking it with a fatty meal is crucial. I also recommend pairing it with vitamin K2 for better absorption. The capsules have high-quality natural ingredients with no taste, and the price is reasonable.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
  • All Researches
9
Vitamin D3 correction improves pain
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
9
Effectiveness of calcitriol combination therapy
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.

Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.

Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
8
Vitamin D reduces fracture risk
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.

Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.

In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Read More

User Reviews

USERS' SCORE
Good
Based on 64 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
8.8
Bone pain relief
After using the supplement for 4 months, my vitamin D levels improved significantly. I experienced a 50% decrease in hair loss, and bone pain is no longer an issue. My memory has also improved greatly, with no sign of forgetfulness. The capsules are easy to swallow.
Read More
9.5
Pain alleviation
This product works like magic. One pill effectively alleviates my back and leg pain. It’s high-quality with excellent ingredients, providing good value for the price. I highly recommend sticking to the dosage of one pill weekly.
Read More
9.5
Supports immunity
Vitamin D3 is essential, particularly for those with immune issues and joint pain. It also fights fatigue and enhances immunity. Taking it with a fatty meal is crucial. I also recommend pairing it with vitamin K2 for better absorption. The capsules have high-quality natural ingredients with no taste, and the price is reasonable.
Read More
9.5
Relieved bone pain
I’m delighted that NOW offers a high-dose D3 in a single gel cap. I'm using it as part of a protocol to heal my bone pain. I highly recommend this product for its effectiveness and convenience.
Read More
9.5
Reduces body aches
I was thrilled with the quality of this vitamin. Post-covid, I suffered from autoimmune disease and body aches. Taking vitamin D alongside K2 has significantly improved my condition. The service was excellent, with prompt delivery, and I now feel more energetic and pain-free. I am truly grateful.
Read More

Frequently Asked Questions

Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.

If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.

Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.

In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.

Vitamin D plays a crucial role in bone health, primarily by facilitating calcium absorption in the gut, which is essential for maintaining strong bones. Insufficient levels of Vitamin D can lead to weakened bones, resulting in conditions like osteoporosis or osteomalacia, which often present with bone pain. If you are experiencing bone pain, it may be beneficial to evaluate your Vitamin D levels. Supplementation with Vitamin D can help alleviate pain associated with deficiencies and improve overall bone density.

However, it's important to approach this with care. While Vitamin D can contribute positively to bone health, it is not a standalone solution for all types of bone pain. It's advisable to consult a healthcare provider for a comprehensive assessment and tailored recommendations. They can help determine if your bone pain is related to Vitamin D deficiency or other underlying issues, ensuring you receive the most appropriate treatment plan.

Based on user reviews, the time it takes to see results from taking vitamin D supplements for bone pain varies. Some users have reported noticeable improvements within a few weeks to a couple of months. For example, one user mentioned a significant decrease in bone pain after four months of use (Read Review). Another user noted relief from symptoms like joint pain and fatigue after using the supplement consistently over several weeks (Read Review).

While experiences differ, many reviews suggest that a regular intake over an extended period, typically several weeks to months, is necessary for substantial effects, particularly for those with severe deficiencies. Users also emphasize the importance of using the supplement consistently and often recommend pairing it with vitamin K2 for optimal absorption and results (Read Review). Ultimately, individual results may depend on personal health conditions and adherence to the recommended dosage.

This supplement appears to be supported by scientific research regarding its potential benefits for bone pain, particularly through the role of vitamin D and its analogs. For instance, a study found that low levels of serum 25-hydroxyvitamin D were linked to an increased risk of new vertebral fractures in postmenopausal women recovering from surgery. This suggests that addressing vitamin D deficiency through supplementation may be crucial in reducing bone pain and preventing further fractures in this population [1].

Additionally, research indicates that pre-operative correction of vitamin D3 levels significantly improved post-operative pain control for patients undergoing knee surgery. Those who treated their deficiencies before surgery reported better pain outcomes compared to those who did not [2]. Furthermore, a study involving calcitriol, another form of vitamin D, combined with bisphosphonates showed promise in alleviating bone pain in postmenopausal women suffering from osteoporosis [3]. These findings collectively highlight the importance of maintaining adequate vitamin D levels as a strategy for managing bone pain effectively.

Based on user reviews, many individuals have reported significant improvements in various symptoms after taking vitamin D supplements. A common theme among users is the reduction in hair loss, with one reviewer noting a 50% decrease in this issue after four months of use (Read Review). Additionally, users have experienced alleviation from joint pain and bone discomfort, with one person stating that their back and leg pain effectively vanished after taking just one pill (Read Review). Reports indicate that these supplements also contribute to heightened energy levels and mood improvement, as users mention feeling revitalized and more alert (Read Review).

Improvement in symptoms appears to vary by individual experience, with some noting benefits occurring within weeks, while others found the effects cumulative over several months. Users have highlighted the importance of pairing vitamin D with vitamin K2 for enhanced absorption and effectiveness (Read Review). Overall, positive outcomes surrounding mood enhancement, energy revival, and pain relief have been commonly reported, affirming the supplement's potential role in supporting overall health, particularly for those dealing with deficiencies (Read Review).

Users frequently report that combining vitamin D with vitamin K2 enhances the effectiveness of their supplementation, particularly for alleviating bone pain. Reviewers emphasize that taking these two vitamins together improves absorption and overall health benefits. One user noted that their condition improved significantly after taking vitamin D alongside K2, especially in managing autoimmune disease and related body aches (Read Review). Another mentioned the importance of pairing vitamin D3 with a fatty meal for optimal absorption, reiterating its effectiveness when combined with K2 (Read Review).

Many users have shared positive experiences regarding their bone health after integrating both supplements into their routine. For instance, one reviewer highlighted significant reductions in bone pain after consistently taking vitamin D with K2 (Read Review). Another user reported that maintaining their vitamin D levels along with K2 led to an essential improvement in their bone health and energy levels (Read Review). Overall, user feedback indicates that combining these supplements can yield notable benefits and enhance the management of bone-related discomfort.

When it comes to treating bone pain, research suggests that ensuring adequate vitamin D levels is crucial, especially for individuals recovering from bone-related procedures or dealing with conditions like osteoporosis. One study emphasized that low serum levels of 25-hydroxyvitamin D (25[OH]D) are associated with an increased risk of new vertebral fractures in postmenopausal women. Therefore, adequate vitamin D intake may be pivotal for reducing bone pain and preventing fractures, highlighting the relevance of vitamin D supplementation in these cases [1].

Additionally, another research found that pre-operative correction of vitamin D3 deficiency can significantly alleviate post-operative bone pain following knee surgeries. Patients who received vitamin D3 treatment before their surgery reported better pain control compared to those who were treated afterwards or who initially had adequate levels. This indicates that vitamin D status is a modifiable risk factor that should be addressed prior to surgical procedures to enhance recovery and minimize pain [2]. While the exact optimal dose for vitamin D can vary based on individual needs, integrating vitamin D supplementation with other therapies, such as bisphosphonates, has shown promise in enhancing bone health and reducing pain, particularly in postmenopausal women [3].

8.8
Bone pain relief
After using the supplement for 4 months, my vitamin D levels improved significantly. I experienced a 50% decrease in hair loss, and bone pain is no longer an issue. My memory has also improved greatly, with no sign of forgetfulness. The capsules are easy to swallow.
9.5
Eases joint pain
After discovering my severe vitamin D deficiency, I noted hair loss, depression, and fatigue. After using this product, my hair loss has decreased, and I’ve felt relief from symptoms like joint pain and exhaustion. The long shelf life and weekly dose make it convenient.
9.5
Supports immunity
Vitamin D3 is essential, particularly for those with immune issues and joint pain. It also fights fatigue and enhances immunity. Taking it with a fatty meal is crucial. I also recommend pairing it with vitamin K2 for better absorption. The capsules have high-quality natural ingredients with no taste, and the price is reasonable.
9.5
Pain alleviation
This product works like magic. One pill effectively alleviates my back and leg pain. It’s high-quality with excellent ingredients, providing good value for the price. I highly recommend sticking to the dosage of one pill weekly.
9.5
Revitalisation felt
Thanks to this product, my Vitamin D levels have improved significantly. I previously dealt with bone pain, lethargy, and depression, but now I feel energized and revitalised.
8.8
Enhanced mood
After taking Vitamin D3 for several months, I've experienced incredible results. It has significantly improved my mood and energy levels, even during winter. This "sunshine vitamin" has strengthened my bones and enhanced my immune protection, making me feel healthier and more vibrant every day.
9.5
Reduces body aches
I was thrilled with the quality of this vitamin. Post-covid, I suffered from autoimmune disease and body aches. Taking vitamin D alongside K2 has significantly improved my condition. The service was excellent, with prompt delivery, and I now feel more energetic and pain-free. I am truly grateful.
9.5
High-quality vitamin
I find this D3 vitamin superb, with small capsules that are easy to take. The 50,000 dosage works well, especially combined with vitamin K2. It effectively treats vitamin deficiency, and I've noticed that my bone pain has decreased significantly.
8.8
Strengthened immunity
The vitamin D dosage is remarkable. For maintaining levels, I take a capsule weekly, but for acute deficits, I take it every other day. My family's health has improved significantly, alleviating bone pain and enhancing energy levels. Highly recommended!
8
Vitamin D reduces fracture risk
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.

Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.

In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
9
Vitamin D3 correction improves pain
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9
Effectiveness of calcitriol combination therapy
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.

Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.

Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.

References

  1. Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
  2. Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002
  3. Han K, Wang X. Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study. Medicine (Baltimore). 2024;103:e40171. doi:10.1097/MD.0000000000040171
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